Meldonium Mildronate

Meldonium Mildronate has become very popular performance enhancer among regular and also professional athletes because of its unique properties as stamina enhancement and oxygen metabolism improvement.  Regular people also tend to use Meldonium in their every day lives because it increases overall energy levels and increases productivity. Meldonium originally is made and sold in Latvia by company called Grindeks and distributed in few other neighboring countries, thus the rest of the world can only buy and order Meldonium Mildronate thru online vendors . 

Meldonium uses 

Meldonium use in Coronary heart disease

Studies conducted on animals have revealed that meldonium has a positive effect on the contractility of the myocardium. It has myocardioprotective effects, including protection against catecholamines and alcohol, and can prevent cardiac rhythm disturbances, and reduce the area of myocardial infarction.

Regarding coronary heart disease, analysis of clinical data has indicated that meldonium, when used in conjunction with other antianginal agents, reduces the frequency and intensity of angina attacks and the amount of glyceryl trinitrate administered. In patients with coronary heart disease and ventricular extrasystoles, the drug has a noticeable antiarrhythmic effect. However, it is not as effective in patients with supraventricular extrasystoles. The drug's capacity to reduce oxygen consumption while at rest is of particular importance, as it is considered a criterion for the efficacy of antianginal therapy in CVD. Furthermore, meldonium has a beneficial impact on atherosclerotic processes in coronary and peripheral vessels by decreasing serum total cholesterol and the atherogenicity index.

Chronic heart failure

Numerous clinical trials have examined the role of meldonium in the treatment of heart failure induced by CVD and its ability to increase exercise tolerance and work performance in heart failure patients. The drug has been shown to be effective in heart failure patients when used as part of a combination therapy with other conventional heart failure medications, particularly for patients classified as NYHA functional classes I-III. Meldonium administration enhances myocardial inotropic function and improves exercise tolerance, which enhances patients' quality of life without causing severe side effects. Additionally, a study conducted at the Latvian and Lithuanian Institutes of Cardiology revealed the benefits of meldonium in combination with lisinopril in treating chronic heart failure, including improved peripheral circulation and quality of life and reduced mental and physical stress.

Impact on the CNS

Animal studies have shown that meldonium has antihypoxic and cerebrovascular effects. It optimizes the redistribution of cerebral blood flow to ischemic foci and increases neuronal resistance in hypoxic environments. The drug has a CNS stimulating effect, such as an increase in motor activity and physical performance, stimulation of behavioural responses, and anti-stress effects.