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Mildronate is very controversial in relation to its use in sports, and you may have heard that its name has been involved in sports scandals. That is why many want to buy Mildronate. But do you actually know what Mildronate is? In this article you will learn everything you need to know about Mildronate, the facts, the inaccuracies, why would anyone want to buy Mildronate, and the science behind the name.
Mildronate is the brand name for the drug Meldonium. It is a drug originally developed in Latvia to increase oxygen flow. The World Anti-Doping Agency (WADA) took action to ban the substance in Olympic sports after athletes began using it for performance-enhancing purposes.
Meldonium is mainly manufactured by a Latvian pharmaceutical company called Grindeks. While "Meldonium" is the simple and easily recognizable name of the drug, you can also get to know it in its Latvian spelling: Mildronāts, or the lesser-known names Quaterine, MET-88, THP, trimethylhydrazinium propionate and 3-(2,2,2-trimethylhydraziniumyl)propionate.
For the purposes of this article, we will stick with mildronate and meldonium.
It is quite clear that many would like to get their hands on Mildronate because it can enhance athletic performance and shorten recovery time. This application speaks for itself, because as we know, even after the Shaparova scandal, athletes are still regularly caught taking it. This is not because many of them have a specific disease that can only be treated with Mildronate, but because they use it even after the ban because they see a significant improvement in their overall performance, they just try not to get caught, and if they do, they have to make up a story.
Recently there is another important reason why one would want and need to buy Mildronate, In the light of the pandemic we have seen great increase in people suffering from post viral syndrome, one of the symptoms of this syndrome is fatigue. Mildronate is known to help with daily energy and concentration problems. This means that Mildronate is a pretty logical choice when it comes to treating post viral fatigue. There are a lot of positive anecdotal reports of people using mildronate for fatigue, but little scientific research. I managed to find this scientific paper that includes a case study on the use of mildronate to treat chronic fatigue syndrome. If you would like to read it, you can do so HERE.
1.Meldonium is approved throughout Eastern Europe and Central Asia for a number of health conditions, but is not currently licensed for human use in the United States. But even so, it is widely used among thosw who know about it, and you can buy Mildronate online.
2. Meldonium has a patent in the USA, Germany, France and the UK that allows its use in animals. The patent document states that meldonium is allegedly used to increase growth in animals. However, there are no reports of anyone actually doing this.
3.In 2010, a study showed that meldonium increases sexual behavior and semen quality in boars. The study also shows that meldonium increases the activity of spermatozoa in boar semen.
4. In countries where meldonium is approved, it is used primarily to treat heart disease because, according to Ivar Kalvins, one of the drug's developers, it improves the body's ability to carry oxygen. In many parts of Asia, it is also used to treat circulatory disorders of the brain, such as strokes.
5.Meldonium is still banned for sport by WADA until at least 2023, and the ban has affected many athletes since its introduction in 2016.
6.In 2013, sales of the drug reached 56 million euros and is one of the largest medical exports of Latvia. Surprisingly, sales in Russia surged in the month after Sharapova's ban, doubling over-the-counter sales.
7. large quantities of the drug were supplied to Soviet troops in Afghanistan to improve their endurance at high altitudes. This fact raised the suspicion that meldonium was actually researched and developed for military purposes and not for animal husbandry.
8. A 2005 study found that meldonium in combination with lisinopril (an angiotensin-converting enzyme inhibitor) improved physical performance in people with heart disease. And a 2013 Chinese study found that meldonium was also effective in treating stroke victims.
9. In the countries where meldonium is sold, it is available over-the-counter, anyone who wants to can go to a pharmacy and buy mildronate, and a significant number of the population has used it for shorter or longer periods of time. The main over-the-counter use cases are stress management, recovery from stressful periods of life, and a slight increase in energy levels.
Meldonium is a fatty acid oxidation inhibitor and works by altering pathways for carnitine, a nutrient involved in fat metabolism. This drug is thought to dilate the arteries and increase blood flow (thus increasing the efficiency of oxygen exchange).
In the countries where it is approved, it is mainly used to treat heart diseases such as angina, cardiac arrest and heart failure. It is also commonly used in situations where energy levels have dropped, such as after an infection, but also after stressful times.
WADA classifies it as a metabolic modulator (as does insulin) and defines this class as substances that can alter how certain hormones speed up or slow down various enzymatic reactions in the body. These modulators can block the conversion of testosterone to estrogen in the body. They have been banned from men's competition since 2001 and from women's competition since 2005.
Part of the controversy surrounding meldonium is due to the lack of knowledge about the drug. Many countries are still unsure about its effects. This is mainly because research and approval of such drugs in new countries takes a lot of time and resources. The company behind Mildronate is seeking approval in several regions where they believe it is worthwhile.
Altough people who buy Mildronate know that Meldonium is known to be a substance with few side effects, there are side effects that are seen in some users. According to official sheet let by Mildronate these are some of the most common side effects:
Common (may affect more than 1 in 10 patients):
- Allergic reactions;
- Headache;
- Digestive disorders.
Rare (may affect less than 1 in 1 000 patients):
- increased heartbeat
- Nausea
- Headache
- Tremulousness
- Anxiety
- Dizziness
- Muscle cramps
- metallic taste
Studies have not yet found any serious side effects, the long-term effects are another matter. Mildronate should not be taken for years, the usual duration of use is 1-2 months, after which it is recommended to stop the drug. On the other hand, it has been known for almost 50 years in the countries where it is sold.
1970: The drug is developed by Ivars Kalvins at the Latvian Institute of Organic Synthesis of the USSR.
2015: At the beginning of the year, WADA puts meldonium on its watch list.
2015: At the 2015 European Championships in Baku, meldonium was used very frequently among athletes.13 medalists took meldonium, and it was detected in athletes in 15 of the 21 sports participating in the Games. Most athletes did not report the drug on their doping forms. 66 of 762 urine samples tested positive for meldonium, and only 23 reported taking it.
2015: In December, a study in the journal Drug Testing and Analysis claimed that meldonium "demonstrates an increase in athletes' endurance performance, improved post-exercise rehabilitation, protection against stress, and enhanced activation of central nervous system functions." However, the study itself does not present evidence to support this claim, and talks about two approaches to detecting meldonium with certainty.
2016: On January 1, WADA added meldonium to the list of banned substances because of "evidence of its use by athletes with the intent to enhance performance." It classifies meldonium as a metabolic modulator.
2016: On March 7, former tennis player Maria Sharapova came into the spotlight when she tested positive for the substance. She denied that she had been taking meldonium for over ten years to treat an ongoing medical problem.
2016: Shortly after the Maria Sharapova scandal broke, speculators began selling Mildronate for large sums on Ebay. At that time, Mildronate was selling for 80 to even 120 USD for a box of Midlronate 500mg N60. For comparison, nowadays you can buy Mildronate for about 60 USD per box.
2016: On the same day (March 7), Russian figure dancer Ekaterina Bobrova announced that she had also tested positive for meldonium at the 2016 European Figure Skating Championships. She said she was shocked because she did not believe she had taken the substance.
2016: On April 13, WADA decided to lift the suspensions of athletes who had tested positive for the drug before March 1, 2016, because there was no reliable data on how long it took for meldonium to leave the body, and preliminary tests showed that it could take weeks or months for the drug to leave the body completely.
2016: In May, Russian professional boxer Alexander Povetkin (former two-time World Boxing Association heavyweight champion) tested positive for the substance. An upcoming title fight was postponed indefinitely.
2016: On June 8, Sharapova was banned for two years.
2018:Alexander Krushelnitsky won medals in curling for Russia at the Winter Olympics in Pyongyang and was the subject of extensive doping allegations. The Olympic Committee stripped him of his medals and banned him for two years.
2020: Ukrainian gymnast Oleg Vernyaev, also an Olympic champion, tested positive for mildronate in August 2020 and was banned following a decision by the Gymnastics Ethics Foundation. That means he missed the Tokyo Olympics and may even be banned from the Paris 2024 Games. He also had to pay a fine of almost 5,600 euros.
2022. statistics showed that meldonium was the most commonly used doping agent for Russian athletes.
The manufacturer Grindeks does not believe that the use of meldonium should be banned for athletes, even though the drug mainly reduces cell damage caused by byproducts of carnitine. It may not improve athletic performance, he said, but it can stop tissue damage if a certain area of the body does not get enough blood flow. But now we know that meldonium was the most popular doping drug among Russian athletes. It is very likely that the manufacturer of meldronate will not admit that meldonium is a performance-enhancing drug because it is in his interest to have meldonium taken off the banned list. That would encourage sales. For those who want to increase their energy level, it is definitely worth buying Mildronate and trying it.
Although WADA has banned the substance, scientists have yet to provide solid evidence of meldonium's performance-enhancing properties. Many believe that meldonium was banned too early and immaturely. There is little to no evidence that meldonium has performance-enhancing effects beyond those of permitted substances like caffeine and creatine. And that, dear readers, is the biggest controversy in the entire
